anti-JAM-C antibody [CRAM-18 F26] (azide free)
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Key features and details
- 产品描述:
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- 克隆:
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- 抗原物种:
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CAT.NO. : ARG23311
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Product Details
概述
| 产品描述 | Azide free Rat Monoclonal antibody [CRAM-18 F26] recognizes JAM-C Rat anti Mouse JAM-c antibody, clone CRAM-18 F26 recognises mouse and human Junctional adhesion molecule C (JAM-C), also known as JAM-3 and, historically, as JAM-2. JAM-C is expressed at junctions between endothelial and epithelial cells, as well as on leukocytes, platelets, vascular smooth muscle cells and fibroblasts, amongst other cell types. It plays a role in tight junctions and inflammatory processes and interacts with JAM-A and JAM-B. Clone CRAM-18 F26 has been reported to inhibit transendothelial migration (Johnson-Léger et al. 2002). |
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| 反应物种 | Hu, Ms |
| 应用 | FACS, FuncSt, ICC/IF, IHC-Fr |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | CRAM-18 F26 |
| 同位型 | IgG2a |
| 靶点名称 | JAM-C |
| 抗原物种 | Mouse |
| 抗原 | Recombinant soluble JAM-C. |
| 偶联标记 | Un-conjugated |
| 別名 | JAM-2; JAM-3; Junctional adhesion molecule C; JAM-C; Junctional adhesion molecule 3; JAMC |
应用说明
| 应用建议 |
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| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS. |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | JAM3 |
| 全名 | junctional adhesion molecule 3 |
| 背景介绍 | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] |
| 生物功能 | Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors. [UniProt] |
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