anti-Ly6G + Ly6C antibody [RB6-8C5]

产品描述: Rat Monoclonal antibody [RB6-8C5] recognizes Ly6G + Ly6C
反应物种: Ms
应用: Depletion, FACS, IHC-Fr, IHC-P, IP
特异性: This antibody recognizes the mouse Gr-1 antigen, a ~21 - 25 kDa GPI anchored cell surface protein bearing a single uPAR/Ly6 domain that belongs to the Ly-6 family of proteins (Lee et al. 2013). Clone RB6-8C5 reacts predominantly with the Ly-6G protein but weaker reactivity with the Ly-6C protein has been reported (Fleming et al. 1993). However, other observations dispute the cross-reactivity of clone RB6-8C5 with the Ly-6C protein with the alternative explanation that certain sub-populations of bone marrow cells simultaneously express both Ly-6C and Ly-6G (Nagendra et al. 2007).
宿主: Rat
克隆: Monoclonal
克隆号: RB6-8C5
同位型: IgG2b, kappa
靶点名称: Ly6G + Ly6C

CAT.NO. : ARG22104

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Size:

100 μg

Product Details

概述

产品描述	Rat Monoclonal antibody [RB6-8C5] recognizes Ly6G + Ly6C
反应物种	Ms
应用	Depletion, FACS, IHC-Fr, IHC-P, IP
特异性	This antibody recognizes the mouse Gr-1 antigen, a ~21 - 25 kDa GPI anchored cell surface protein bearing a single uPAR/Ly6 domain that belongs to the Ly-6 family of proteins (Lee et al. 2013). Clone RB6-8C5 reacts predominantly with the Ly-6G protein but weaker reactivity with the Ly-6C protein has been reported (Fleming et al. 1993). However, other observations dispute the cross-reactivity of clone RB6-8C5 with the Ly-6C protein with the alternative explanation that certain sub-populations of bone marrow cells simultaneously express both Ly-6C and Ly-6G (Nagendra et al. 2007).
宿主	Rat
克隆	Monoclonal
克隆号	RB6-8C5
同位型	IgG2b, kappa
靶点名称	Ly6G + Ly6C
抗原物种	Mouse
偶联标记	Un-conjugated
別名	Gr1; Gr-1; Ly-6G

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
缓冲液	BBS (pH 8.2)
浓度	0.5 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 546644 Mouse Ly6g
基因名称	Ly6g
全名	lymphocyte antigen 6 complex, locus G
背景介绍	Ly6G is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. Ly6G is a good marker for detection of peripheral neutrophils. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. Physiological role of Ly6G remains still unclear. Its treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses. _x000D_
产品亮点	Related Antibody Duos and Panels: ARG30326 Inflammatory Cell Antibody Panel (for mouse) ARG30335 Mouse MDSC Marker Antibody Duo Related products: Ly6 antibodies; Ly6 ELISA Kits; Ly6 Duos / Panels; Anti-Rat IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Exploring Antiviral Immune Response Anti-SerpinB9 therapy, a new strategy for cancer therapy
研究领域	Mouse Inflammatory Cell Marker antibody; Neurophil Marker antibody; Mouse MDSC Marker antibody; Myeloid-derived suppressor cell antibody
预测分子量	12 kDa

检测图片 (1)

ARG22104 anti-Ly6G + Ly6C antibody [RB6-8C5] IHC-Fr image
Immunohistochemistry: Mouse spleen section stained with ARG22104 anti-Ly6G + Ly6C antibody [RB6-8C5] followed by ARG21706 Mouse anti-Rat IgG2b antibody [2B10A8] (FITC).

参考文献

Downregulation of AKT/mTOR signaling pathway for Salmonella-mediated autophagy in human anaplastic thyroid cancer

IHC-P / Mouse

Li-Hsien Wu et al.
J Cancer, (2022)