anti-M-CSF antibody [21]
![anti-M-CSF antibody [21]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG10025
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [21] recognizes M-CSF |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | Does not cross react with BSA or other human cytokines tested such as IL-1β, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF-β and TNF-α. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 21 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | M-CSF |
| 抗原物种 | Human |
| 抗原 | Purified recombinant human M-CSF (rhM-CSF) |
| 偶联标记 | Un-conjugated |
| 別名 | Macrophage colony-stimulating factor 1; CSF-1; Lanimostim; M-CSF; MCSF |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G affinity purified |
| 缓冲液 | 0.01M PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P09603 Human Macrophage colony-stimulating factor 1 |
|---|---|
| 基因名称 | CSF1 |
| 全名 | colony stimulating factor 1 (macrophage) |
| 背景介绍 | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| 生物功能 | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody |
| 预测分子量 | 60 kDa |
| 翻译后修饰 | N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated. |
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