anti-MAdCAM1 antibody [314G8] (Biotin)

产品描述: Biotin-conjugated Mouse Monoclonal antibody [314G8] recognizes MAdCAM1Mouse anti Human MAdCAM-1 antibody, clone 314G8 recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyer's patches and mesenteric lymph nodes. MAdCAM-1 expression has also been reported in the gut lamina propria but clone 314G8 does not recognize MAdCAM-1 in these tissues. Clone 314G8 reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognized by clone 314G8. Clone 314G8 is reported to block the interaction of MAdCAM-1 with alpha 4 beta 7 (Leung et al. 2004).
反应物种: Hu
应用: ELISA
宿主: Mouse
克隆: Monoclonal
克隆号: 314G8
同位型: IgG1
靶点名称: MAdCAM1
抗原物种: Human

CAT.NO. : ARG23264

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Size:

50 μg

Product Details

概述

产品描述	Biotin-conjugated Mouse Monoclonal antibody [314G8] recognizes MAdCAM1 Mouse anti Human MAdCAM-1 antibody, clone 314G8 recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyer's patches and mesenteric lymph nodes. MAdCAM-1 expression has also been reported in the gut lamina propria but clone 314G8 does not recognize MAdCAM-1 in these tissues. Clone 314G8 reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognized by clone 314G8. Clone 314G8 is reported to block the interaction of MAdCAM-1 with alpha 4 beta 7 (Leung et al. 2004).
反应物种	Hu
应用	ELISA
宿主	Mouse
克隆	Monoclonal
克隆号	314G8
同位型	IgG1
靶点名称	MAdCAM1
抗原物种	Human
抗原	Recombinant soluble MAdCAM-1-fc fusion protein.
偶联标记	Biotin
別名	Mucosal addressin cell adhesion molecule 1; hMAdCAM-1; MAdCAM-1; MACAM1

应用说明

应用建议

应用	推荐稀释比
ELISA	Assay-dependent

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS, 0.09% Sodium azide and 1% BSA.
抗菌剂	0.09% Sodium azide
稳定剂	1% BSA
浓度	0.1 mg/ml
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8174 Human MADCAM1 Swiss-port # Q13477 Human Mucosal addressin cell adhesion molecule 1
基因名称	MADCAM1
全名	mucosal vascular addressin cell adhesion molecule 1
背景介绍	The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
生物功能	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. [UniProt]
预测分子量	40 kDa
翻译后修饰	The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. [UniProt]

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