anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC)
![anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC)](/upload/image/products/ARG42329_FACS_2_210_205.jpg)
![anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC)](/upload/image/products/ARG42329_FACS_1.jpg)
![anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC)](/upload/image/products/ARG42329_FACS_2.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 不反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
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Brand:
CAT.NO. : ARG42329
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [UIC2] recognizes MDR1 / P Glycoprotein 1 |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Ms, Rat |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | UIC2 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | MDR1 / P Glycoprotein 1 |
| 抗原物种 | Human |
| 抗原 | NIH/3T3 cells transfected with Human MDR1 cDNA. |
| 偶联标记 | APC |
| 別名 | PGY1; ABC20; P-GP; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; CD antigen CD243; GP170; CLCS; CD243; MDR1; EC 3.6.3.44; P-glycoprotein 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ABCB1 |
| 全名 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| 背景介绍 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
| 生物功能 | Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 141 kDa |
检测图片 (2)
ARG42329 anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC) FACS image
Flow Cytometry: HepG2 cells stained with ARG42329 anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
ARG42329 anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC) FACS image
Flow Cytometry: Separation of HepG2 cells (red-filled) from Human peripheral whole blood cells (black-dashed). Cells were stained with ARG42329 anti-MDR1 / P Glycoprotein 1 antibody [UIC2] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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