anti-MNAT1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57880
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MNAT1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MNAT1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-309 of Human MNAT1 (NP_002422.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Cyclin-G1-interacting protein; RING finger protein 66; RNF66; MAT1; CDK-activating kinase assembly factor MAT1; CAP35; TFB3; CDK7/cyclin-H assembly factor; Menage a trois; RING finger protein MAT1; p36; p35 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | 293T | ||||||
| 实际分子量 | 36 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P51948 Human CDK-activating kinase assembly factor MAT1 Swiss-port # P51949 Mouse CDK-activating kinase assembly factor MAT1 |
|---|---|
| 基因名称 | MNAT1 |
| 全名 | MNAT CDK-activating kinase assembly factor 1 |
| 背景介绍 | The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| 生物功能 | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 36 kDa |
检测图片 (2)
ARG57880 anti-MNAT1 antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG57880 anti-MNAT1 antibody at 1:1000 dilution.
ARG57880 anti-MNAT1 antibody IP image
Immunoprecipitation: 200 µg extracts of 293T cells were immunoprecipitated and stained with ARG57880 anti-MNAT1 antibody at 1:1000 dilution.
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