anti-Nav1.8 Na+ Channel antibody [S134-12]
![anti-Nav1.8 Na+ Channel antibody [S134-12]](/upload/image/products/ARG56141_IF_1_210_205.jpg)
![anti-Nav1.8 Na+ Channel antibody [S134-12]](/upload/image/products/ARG56141_WB_Sheet_Rev_MsBrain_171020.jpg)
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG56141
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [S134-12] recognizes Nav1.8 Na+ Channel |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | This antibody recognizes Human, Mouse, and Rat Nav1.8. It does not cross-react with other Nav channels. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S134-12 |
| 同位型 | IgG2a |
| 靶点名称 | Nav1.8 Na+ Channel |
| 抗原物种 | Rat |
| 抗原 | Fusion protein around aa. 1724-1956 (cytoplasmic C-terminus) of Rat Nav1.8 |
| 偶联标记 | Un-conjugated |
| 別名 | Voltage-gated sodium channel subunit alpha Nav1.8; Nav1.8; PN3; Sodium channel protein type X subunit alpha; FEPS2; SNS; Sodium channel protein type 10 subunit alpha; Peripheral nerve sodium channel 3; hPN3 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Rat dorsal root ganglia or lysate of COS cells transiently expressing Nav1.8. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SCN10A |
| 全名 | sodium channel, voltage gated, type X alpha subunit |
| 背景介绍 | The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| 生物功能 | Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. [UniProt] |
| 预测分子量 | 221 kDa |
| 翻译后修饰 | Ubiquitinated by NEDD4L; which promotes its endocytosis. Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
检测图片 (2)
ARG56141 anti-Nav1.8 Na+ Channel antibody [S134-12] WB image
Western blot: 20 µg of Mouse brain lysate stained with ARG56141 anti-Nav1.8 Na+ Channel antibody [S134-12] at 1:500 dilution.
ARG56141 anti-Nav1.8 Na+ Channel antibody [S134-12] IF image
Immunofluorescence: Rat dorsal root ganglia cryosections stained with ARG56141 anti-Nav1.8 Na+ Channel antibody [S134-12].
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