anti-Nkx 2.2 antibody [NX2/294]
CAT.NO. : ARG56172
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概述
产品描述 | Mouse Monoclonal antibody [NX2/294] recognizes Nkx 2.2 |
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反应物种 | Hu, Rat |
应用 | IHC-P |
宿主 | Mouse |
克隆 | Monoclonal |
克隆号 | NX2/294 |
同位型 | IgG2b, kappa |
靶点名称 | Nkx 2.2 |
抗原物种 | Human |
抗原 | Human Nkx2.2 recombinant protein. |
偶联标记 | Un-conjugated |
別名 | Homeobox protein NK-2 homolog B; NKX2.2; Homeobox protein Nkx-2.2; NKX2B |
应用说明
应用建议 |
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应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
形式 | Liquid |
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纯化 | Purification with Protein G. |
缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA. |
抗菌剂 | 0.05% Sodium azide |
稳定剂 | 0.1 mg/ml BSA |
浓度 | 0.2 mg/ml |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | NKX2-2 |
全名 | NK2 homeobox 2 |
背景介绍 | The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008] |
生物功能 | Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). [UniProt] |
细胞定位 | Nuclear |
预测分子量 | 30 kDa |
检测图片 (3)
ARG56172 anti-Nkx 2.2 antibody [NX2/294] IHC-P image
Immunohistochemistry: Ewing's sarcoma stained with ARG56172 anti-Nkx 2.2 antibody [NX2/294].
ARG56172 anti-Nkx 2.2 antibody [NX2/294] IHC-P image
Immunohistochemistry: Human pancreas stained with ARG56172 anti-Nkx 2.2 antibody [NX2/294].
ARG56172 anti-Nkx 2.2 antibody [NX2/294] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Rat pancreas stained with ARG56172 anti-Nkx 2.2 antibody [NX2/294].
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