anti-NMDAR1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG63998
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes NMDAR1 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms, Dog |
| 应用 | WB |
| 特异性 | This antibody is expected to recognise all three reported isoforms (NP_000823.4; NP_067544.1; NP_015566.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NMDAR1 |
| 抗原物种 | Human |
| 抗原 | C-TQERVNNSNKKE |
| 偶联标记 | Un-conjugated |
| 別名 | NMDA1; GluN1; MRD8; NMD-R1; Glutamate receptor ionotropic, NMDA 1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NR1; NMDAR1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P35439 Rat Glutamate receptor ionotropic, NMDA 1 Swiss-port # Q05586 Human Glutamate receptor ionotropic, NMDA 1 |
|---|---|
| 背景介绍 | The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 105 kDa |
| 翻译后修饰 | NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. |
检测图片 (1)
ARG63998 anti-NMDAR1 antibody WB image
Western blot: 35 µg of Human amygdala (A) and Rat brain (B) lysates (in RIPA buffer) stained with ARG63998 anti-NMDAR1 antibody at 1 µg/ml dilution and incubated at RT for 1 hour.
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