anti-NR2F6 antibody [EM-51]
![anti-NR2F6 antibody [EM-51]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
-
Brand:
CAT.NO. : ARG42440
US＄ Please choose
US＄ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [EM-51] recognizes NR2F6 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 特异性 | The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | EM-51 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | NR2F6 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human NR2F6 protein (expressed in E. coli). |
| 偶联标记 | Un-conjugated |
| 別名 | EAR-2; V-erbA-related protein 2; Nuclear receptor subfamily 2 group F member 6; ERBAL2; EAR2 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P10588 Human Nuclear receptor subfamily 2 group F member 6 |
|---|---|
| 基因名称 | NR2F6 |
| 全名 | nuclear receptor subfamily 2, group F, member 6 |
| 生物功能 | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 43 kDa |
New Products
