anti-NT-proBNP antibody [11D1]

CAT.NO. : ARG10406

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Size:

200 μg

Product Details

概述

产品描述	Mouse Monoclonal antibody [11D1] recognizes NT-proBNP
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
克隆号	11D1
同位型	IgG1
靶点名称	NT-proBNP
抗原物种	Human
抗原	Synthetic N-terminal pro brain natriuretic peptide (NT-proBNP), corresponding to aa. 28-45
偶联标记	Un-conjugated
別名	4-27; Natriuretic peptides B; 1-28; 1-29; 5-32; BNP; 1-32; 1-30; BNP-32; 5-29; 2-31; 4-30; 4-31; 4-32; 3-29; Gamma-brain natriuretic peptide; 3-30; 5-31; 3-32; 4-29

应用说明

应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Protein A affinity purified.
缓冲液	PBS (pH 7.4) and 0.1% Sodium azide
抗菌剂	0.1% Sodium azide
浓度	1.0-2.0 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 4879 Human NPPB Swiss-port # P16860 Human Natriuretic peptides B
基因名称	NPPB
全名	natriuretic peptide B
背景介绍	This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
生物功能	Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. [UniProt]
研究领域	Cell Biology and Cellular Response antibody; Signaling Transduction antibody
预测分子量	15 kDa
翻译后修饰	The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).

检测图片 (2)

ARG10406 anti-NT-proBNP antibody [11D1] WB image
Western blot: Human recombinant NT-proBNP expressed in E. coli stained with 1) ARG10408 anti-NT-proBNP antibody [15F11] and 2) ARG10406 anti-NT-proBNP antibody [11D1], after Tricine-SDS gel electrophoresis.
ARG10406 anti-NT-proBNP antibody [11D1] WB image
Western blot: Human recombinant proBNP expressed in mammalian cells stained with 1) ARG10408 anti-NT-proBNP antibody [15F11] and 2) ARG10406 anti-NT-proBNP antibody [11D1], after Tricine-SDS gel electrophoresis. ARG10406 does not recognize glycosylated proBNP expressed in the mammalian cell line.

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