anti-NTAL / LAB antibody [NAP-07] (PE)
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [NAP-07] recognizes NTAL / LAB |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS |
| 特异性 | The clone NAP-07 reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | NAP-07 |
| 同位型 | IgG1 |
| 靶点名称 | NTAL / LAB |
| 抗原物种 | Human |
| 抗原 | Recombinant cytoplasmic domain (aa 91-243) of human NTAL. |
| 偶联标记 | PE |
| 別名 | Membrane-associated adapter molecule; Non-T-cell activation linker; WSCR5; WBSCR15; Linker for activation of B-cells; HSPC046; LAB; WBSCR5; NTAL; Williams-Beuren syndrome chromosomal region 15 protein; Linker for activation of T-cells family member 2; Williams-Beuren syndrome chromosomal region 5 protein |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # Q9GZY6 Human Linker for activation of T-cells family member 2 Swiss-port # Q9JHL0 Mouse Linker for activation of T-cells family member 2 |
|---|---|
| 基因名称 | LAT2 |
| 全名 | linker for activation of T cells family, member 2 |
| 背景介绍 | NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function. |
| 生物功能 | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. [UniProt] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2. May be polyubiquitinated. |
ARG53957 anti-NTAL / LAB antibody [NAP-07] (PE) FACS image
Flow Cytometry: Human peripheral blood lymphocytes stained with ARG53957 anti-NTAL / LAB antibody [NAP-07] (PE).
克隆号文献
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
WB / Mouse
Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells.
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor.
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