anti-NUB1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes NUB1 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mk |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NUB1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human NUB1 |
| 偶联标记 | Un-conjugated |
| Protein Full name | NEDD8 ultimate buster 1 |
| 別名 | NUB1; Negative Regulator Of Ubiquitin Like Proteins 1; NYREN18; NUB1L; BS4; Renal Carcinoma Antigen NY-REN-18; NEDD8 Ultimate Buster-1; NEDD8 Ultimate Buster 1; Negative Regulator Of Ubiquitin-Like Proteins 1 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | NUB1 |
| 全名 | Negative Regulator Of Ubiquitin Like Proteins 1 |
| 背景介绍 | This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. |
| 生物功能 | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. |
| 细胞定位 | Nucleus |
| 预测分子量 | 71 kDa |
ARG44174 anti-NUB1 antibody IHC-P image
Immunohistochemistry: Human adrenal adenomas stained with ARG44174 anti-NUB1 antibody at 2 μg/mL dilution.
ARG44174 anti-NUB1 antibody WB image
Western blot: MCF-7 and A549 stained with ARG44174 anti-NUB1 antibody at 0.25 μg/mL dilution.
ARG44174 anti-NUB1 antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG44174 anti-NUB1 antibody at 5 μg/mL dilution.
ARG44174 anti-NUB1 antibody FACS image
Flow Cytometry: K562 stained with ARG44174 anti-NUB1 antibody at 1 μg/1x10^6 cells dilution.
ARG44174 anti-NUB1 antibody WB image
Western blot: Rat liver and PC-12 stained with ARG44174 anti-NUB1 antibody at 0.25 μg/mL dilution.
ARG44174 anti-NUB1 antibody IHC-P image
Immunohistochemistry: Human bladder urothelial carcinoma stained with ARG44174 anti-NUB1 antibody at 2 μg/mL dilution.
ARG44174 anti-NUB1 antibody WB image
Western blot: NIH/3T3 stained with ARG44174 anti-NUB1 antibody at 0.25 μg/mL dilution.
ARG44174 anti-NUB1 antibody WB image
Western blot: COS-7 stained with ARG44174 anti-NUB1 antibody at 0.25 μg/mL dilution.
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