anti-PSMD4 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes PSMD4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PSMD4 |
| 抗原物种 | Human |
| 抗原 | Human PSMD4 recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | 26S proteasome non-ATPase regulatory subunit 4 |
| 別名 | PSMD4; Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4; AF; Rpn10; AF-1; S5A; Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4; 26S Proteasome Non-ATPase Regulatory Subunit 4; 26S Proteasome Regulatory Subunit S5A; Proteasome 26S Subunit, Non-ATPase 4; Multiubiquitin Chain-Binding Protein; Antisecretory Factor 1; MCB1; ASF; 26S Proteasome Regulatory Subunit RPN10; S5a/Antisecretory Factor Protein; Angiocidin; PUB-R5 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 数据库连接 | Swiss-port # O35226 Mouse 26S proteasome non-ATPase regulatory subunit 4 Swiss-port # P55036 Human 26S proteasome non-ATPase regulatory subunit 4 |
|---|---|
| 基因名称 | PSMD4 |
| 全名 | Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4 |
| 背景介绍 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. |
| 生物功能 | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. |
| 细胞定位 | Proteasome |
| 预测分子量 | 41 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation |
ARG43998 anti-PSMD4 antibody IHC-P image
Immunohistochemistry: Human urothelial carcinoma stained with ARG43998 anti-PSMD4 antibody at 2 μg/ml dilution.
ARG43998 anti-PSMD4 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG43998 anti-PSMD4 antibody at 5 μg/ml dilution.
ARG43998 anti-PSMD4 antibody WB image
Western blot: K562 and Hela stained with ARG43998 anti-PSMD4 antibody at 0.25 μg/mL dilution.
ARG43998 anti-PSMD4 antibody FACS image
Flow Cytometry: U2OS cells stained with ARG43998 anti-PSMD4 antibody (blue) at 1 μg/1x10^6 cells dilution.
ARG43998 anti-PSMD4 antibody IHC-P image
Immunohistochemistry: Human liver cancer stained with ARG43998 anti-PSMD4 antibody at 2 μg/ml dilution.
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