anti-SH3RF1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原表位:
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Brand:
CAT.NO. : ARG44930
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes SH3RF1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | SH3RF1 |
| 抗原物种 | Human |
| 抗原表位 | GNSSATKPDK DSKKEKKGLL KLLSGASTKR KPRVSPPASP TLEVELGSAE LPLQGAVGPE LPPGGGHGRA GSCPVDGDGP VTTAVAGAAL AQDAFHRKAS SLDSAVPIAP PPRQACSSLG PVLNESRPVV CERHRVVVSY PPQSEAELEL KEGDIVFVHK KREDGWFKGT LQRNGKTGLF |
| 偶联标记 | Un-conjugated |
| 別名 | SH3RF1; SH3 Domain Containing Ring Finger 1; RNF142; POSH; KIAA1494; SH3MD2; SH3 Domain-Containing RING Finger Protein 1; RING-Type E3 Ubiquitin Transferase SH3RF1; E3 Ubiquitin-Protein Ligase SH3RF1; SH3 Multiple Domains Protein 2; SH3 Multiple Domains 2; Plenty Of SH3 Domains; Plenty Of SH3s; Putative E3 Ubiquitin-Protein Ligase SH3RF1; Ring Finger Protein 142; RING Finger Protein 142; Protein POSH; EC 2.3.2.27; EC 6.3.2; POSH1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q69ZI1 Mouse E3 ubiquitin-protein ligase SH3RF1 Swiss-port # Q7Z6J0 Human E3 ubiquitin-protein ligase SH3RF1 |
|---|---|
| 基因名称 | SH3RF1 |
| 全名 | SH3 Domain Containing Ring Finger 1 |
| 背景介绍 | This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4+ and CD8+ T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4+ T-cells and the activation of MAPK8/JNK1 in CD8+ T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly |
| 细胞定位 | Cell projection, Cytoplasm, Golgi apparatus |
| 预测分子量 | 93 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation |
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