anti-Siglec 8 antibody [7C9]
![anti-Siglec 8 antibody [7C9]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG11042
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [7C9] recognizes Siglec 8 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 7C9 |
| 同位型 | IgG1 |
| 靶点名称 | Siglec 8 |
| 抗原物种 | Human |
| 抗原 | SIGLEC8-Fc protein, containing entire extracellular region of Human Siglec-8 fused with the Fc region of Human IgG1. |
| 偶联标记 | Un-conjugated |
| 別名 | Siglec-8; Sialic acid-binding Ig-like lectin 8; SIGLEC-8; SAF-2; Sialoadhesin family member 2; SAF2; SIGLEC8L |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | SIGLEC8 transfected CHO cells. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9NYZ4 Human Sialic acid-binding Ig-like lectin 8 |
|---|---|
| 基因名称 | SIGLEC8 |
| 全名 | sialic acid binding Ig-like lectin 8 |
| 背景介绍 | Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010] |
| 生物功能 | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein [UniProt] |
| 预测分子量 | 54 kDa |
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