anti-SMPD1 / Acid Sphingomyelinase antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59526
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SMPD1 / Acid Sphingomyelinase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SMPD1 / Acid Sphingomyelinase |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human SMPD1 / Acid Sphingomyelinase. |
| 偶联标记 | Un-conjugated |
| 別名 | aSMase; EC 3.1.4.12; NPD; ASMASE; Sphingomyelin phosphodiesterase; Acid sphingomyelinase; ASM |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | THP-1 + PMA | ||||||
| 实际分子量 | 60 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SMPD1 |
| 全名 | sphingomyelin phosphodiesterase 1, acid lysosomal |
| 背景介绍 | The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010] |
| 生物功能 | Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. [UniProt] |
| 细胞定位 | Lysosome. Secreted. [UniProt] |
| 预测分子量 | 70 kDa |
检测图片 (2)
ARG59526 anti-SMPD1 / Acid Sphingomyelinase antibody WB image
Western blot: THP-1 cells were untreated or treated by PMA (80 nM) for overnight. 25 µg of cell lysates stained with ARG59526 anti-SMPD1 / Acid Sphingomyelinase antibody at 1:1000 dilution.
ARG59526 anti-SMPD1 / Acid Sphingomyelinase antibody WB image
Western blot: 25 µg of Rat liver, Mouse liver and HepG2 cell lysates stained with ARG59526 anti-SMPD1 / Acid Sphingomyelinase antibody at 1:1000 dilution.
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