anti-STAM1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57614
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes STAM1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | STAM1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human STAM1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Signal transducing adapter molecule 1 |
| 別名 | STAM; Signal Transducing Adaptor Molecule; STAM1; Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif); Signal Transducing Adapter Molecule 1; STAM-1; HSE1 Homolog (S. Cerevisiae); HSE1 Homolog |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Jurkat | ||||
| 实际分子量 | 70 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P70297 Mouse Signal transducing adapter molecule 1 Swiss-port # Q92783 Human Signal transducing adapter molecule 1 |
|---|---|
| 基因名称 | STAM |
| 全名 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| 背景介绍 | This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] |
| 生物功能 | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [UniProt] |
| 细胞定位 | Cytoplasm, Endosome, Membrane |
| 预测分子量 | 59 kDa |
| 翻译后修饰 | sopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (1)
ARG57614 anti-STAM1 antibody WB image
Western blot: 25 µg of Jurkat cell lysate stained with ARG57614 anti-STAM1 antibody at 1:1000 dilution.
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