anti-TAB1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原:
- 偶联标记:
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Brand:
CAT.NO. : ARG54684
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes TAB1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ELISA, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TAB1 |
| 抗原 | Synthetic peptide (13 aa) within aa. 220-270 of Human TAB1. |
| 偶联标记 | Un-conjugated |
| 別名 | MAP3K7IP1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; 3'-Tab1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | 3T3 Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q15750 Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Swiss-port # Q8CF89 Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 |
|---|---|
| 基因名称 | TAB1 |
| 全名 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| 背景介绍 | TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1. |
| 生物功能 | May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. |
检测图片 (3)
ARG54684 anti-TAB1 antibody ICC/IF image
Immunocytochemistry: K562 cells stained with ARG54684 anti-TAB1 antibody at 1 μg/ml.
ARG54684 anti-TAB1 antibody ICC/IF image
Immunofluorescence: 3T3 cells stained with ARG54684 anti-TAB1 antibody at 2 μg/ml.
ARG54684 anti-TAB1 antibody WB image
Western blot: 3T3 cell lysate stained with ARG54684 anti-TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 μg/ml.
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