anti-TAL1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes TAL1
  • 反应物种: Hu, Ms
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: TAL1
  • 抗原物种: Mouse
  • 抗原: Synthetic peptide within a.a 150-200 of Mouse TAL1 protein.
  • Brand:
CAT.NO. : ARG43638
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes TAL1
反应物种Hu, Ms
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称TAL1
抗原物种Mouse
抗原Synthetic peptide within a.a 150-200 of Mouse TAL1 protein.
偶联标记Un-conjugated
Protein Full nameT-cell acute lymphocytic leukemia protein 1
別名tal-1; SCL; TCL5; bHLHa17; Class A basic helix-loop-helix protein 17; T-cell leukemia/lymphoma protein 5; Stem cell protein; T-cell acute lymphocytic leukemia protein 1; TAL-1
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量35-50 kDa
属性
形式Liquid
纯化Purification with Protein A and immunogen peptide.
缓冲液PBS and 0.09% Sodium azide.
抗菌剂0.09% Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 21349 Mouse TAL1

GeneID: 6886 Human TAL1

Swiss-port # P17542 Human T-cell acute lymphocytic leukemia protein 1

Swiss-port # P22091 Mouse T-cell acute lymphocytic leukemia protein 1 homolog

基因名称Tal1
全名T cell acute lymphocytic leukemia 1
背景介绍Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]
生物功能Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). [UniProt]
细胞定位Nucleus
预测分子量34 kDa
翻译后修饰Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).

Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). [UniProt]
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