anti-TUSC4 / NPRL2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG64424
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes TUSC4 / NPRL2 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | TUSC4 / NPRL2 |
| 抗原物种 | Human |
| 抗原 | QYSNVYCPTPKV |
| 偶联标记 | Un-conjugated |
| 別名 | TUSC4; Gene 21 protein; NPR2; NPR2-like protein; Tumor suppressor candidate 4; Nitrogen permease regulator 2-like protein; G21 protein; NPR2L |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q8WTW4 Human Nitrogen permease regulator 2-like protein |
|---|---|
| 基因名称 | NPRL2 |
| 全名 | nitrogen permease regulator-like 2 (S. cerevisiae) |
| 生物功能 | Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. [UniProt] |
| 研究领域 | Cancer antibody; Gene Regulation antibody |
| 预测分子量 | 44 kDa |
检测图片 (1)
ARG64424 anti-TUSC4 / NPRL2antibody WB image
Western Blot: Human Muscle lysate (35 µg protein in RIPA buffer) stained with ARG64424 anti-TUSC4 / NPRL2 (aa 140 to 151) antibody at 0.1 µg/ml dilution.
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