anti-VAMP2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG41006
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes VAMP2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | The antibody might also react to VAMP1 (75%) and VAMP3 (86%) based on sequence homology analysis. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | VAMP2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide within aa. 1-100 of Human VAMP2 (NP_055047.2). |
| 偶联标记 | Un-conjugated |
| 別名 | SYB2; Synaptobrevin-2; Vesicle-associated membrane protein 2; VAMP-2 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat brain | ||||||
| 实际分子量 | 16 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VAMP2 |
| 全名 | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| 背景介绍 | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. [UniProt] |
| 细胞定位 | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane. Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). [UniProt] |
| 预测分子量 | 13 kDa |
| 翻译后修饰 | Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2. [UniProt] |
检测图片 (2)
ARG41006 anti-VAMP2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat testis stained with ARG41006 anti-VAMP2 antibody at 1:100 dilution.
ARG41006 anti-VAMP2 antibody WB image
Western blot: 25 µg of Rat brain lysate stained with ARG41006 anti-VAMP2 antibody at 1:3000 dilution.
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