anti-WIPI2 antibody [2A2]

产品描述: Mouse Monoclonal antibody [2A2] recognizes WIPI2This antibody recognizes WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2), also known as WIPI49-like protein 2. WIPI2 is a 454 amino acid ~54kDa autophagosomal marker containing three WD repeats. WIPI2 a mammalian orthologue of the yeast protein Atg18 and is similarly recruited to early autophagosomal structures and is required for their maturation into mature autophagosomes (Polson et al. 2010).Mouse anti Human WIPI2 antibody, clone 2A2 has been used for the immunofluorescent detection of WIPI2 in the human retinal epithelial cell line RPE1 (MacVicar and Lane 2014).
反应物种: Hu, Ms
应用: ICC/IF, IHC-P, IP, WB
宿主: Mouse
克隆: Monoclonal
克隆号: 2A2
同位型: IgG1
靶点名称: WIPI2
抗原物种: Human

CAT.NO. : ARG22592

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Size:

50 μg

Product Details

概述

产品描述	Mouse Monoclonal antibody [2A2] recognizes WIPI2 This antibody recognizes WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2), also known as WIPI49-like protein 2. WIPI2 is a 454 amino acid ~54kDa autophagosomal marker containing three WD repeats. WIPI2 a mammalian orthologue of the yeast protein Atg18 and is similarly recruited to early autophagosomal structures and is required for their maturation into mature autophagosomes (Polson et al. 2010).Mouse anti Human WIPI2 antibody, clone 2A2 has been used for the immunofluorescent detection of WIPI2 in the human retinal epithelial cell line RPE1 (MacVicar and Lane 2014).
反应物种	Hu, Ms
应用	ICC/IF, IHC-P, IP, WB
宿主	Mouse
克隆	Monoclonal
克隆号	2A2
同位型	IgG1
靶点名称	WIPI2
抗原物种	Human
抗原	Synthetic peptide corresponding to the C-terminus of WIPI2b (CSALRLDEDSEHPPMILRTD)
偶联标记	Un-conjugated
別名	WD repeat domain phosphoinositide-interacting protein 2; WIPI-2; 2510001I10Rik; 1110018O08Rik

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 0.09% Sodium azide
抗菌剂	0.09% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 26100 Human WIPI2 GeneID: 74781 Mouse WIPI2 Swiss-port # Q80W47 Mouse WD repeat domain phosphoinositide-interacting protein 2 Swiss-port # Q9Y4P8 Human WD repeat domain phosphoinositide-interacting protein 2
基因名称	Wipi2
全名	WD repeat domain, phosphoinositide interacting 2
生物功能	Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes. [UniProt]
预测分子量	49 kDa

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