anti-XRCC1 antibody [33-2-5]
![anti-XRCC1 antibody [33-2-5]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
Product Details
| 产品描述 | Mouse Monoclonal antibody [33-2-5] recognizes XRCC1 |
|---|---|
| 反应物种 | Hu, Rat, Hm |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 33-2-5 |
| 同位型 | IgG2b |
| 靶点名称 | XRCC1 |
| 抗原物种 | Human |
| 抗原 | Recombinant full length protein (Human). |
| 偶联标记 | Un-conjugated |
| 別名 | X-ray repair cross-complementing protein 1; DNA repair protein XRCC1; RCC |
| 应用说明 | Flow Cyt: 1 µg for 10^6 cells. ICC/IF: 1/200. IHC-Fr: 1/50 - 1/100. IHC-P: 1/50 - 1/100. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|---|
| 阳性对照 | Testis |
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purified |
| 缓冲液 | PBS, 1% BSA and 0.05% Sodium azide |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 1% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | XRCC1 |
| 全名 | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| 背景介绍 | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
| 生物功能 | Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. [UniProt] |
| 细胞定位 | Nucleus. |
| 研究领域 | Cancer antibody; Gene Regulation antibody; Metabolism antibody |
| 预测分子量 | 69 kDa |
| 翻译后修饰 | Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF. Sumoylated. |
克隆号文献
DNA breaks and chromosomal aberrations arise when replication meets base excision repair.
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.
PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.
WB /
Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis.
Targeting XRCC1 deficiency in breast cancer for personalized therapy.
WB / Human
Clinicopathological and functional significance of XRCC1 expression in ovarian cancer.
IHC / Human
HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.
ICC/IF / Mouse
DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication.
WB / Rat
Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.
IP / Chinese Hamster
In situ analysis of repair processes for oxidative DNA damage in mammalian cells.
ICC/IF / Human
Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering.
WB / Rabbit
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