anti-ZEB1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG66993
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ZEB1 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ZEB1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the middle region of Human ZEB1. |
| 偶联标记 | Un-conjugated |
| 別名 | Transcription factor 8; DELTAEF1; PPCD3; TCF-8; AREB6; BZP; TCF8; NIL-2-A zinc finger protein; FECD6; NIL2A; Zinc finger E-box-binding homeobox 1; Negative regulator of IL2; ZFHX1A; ZFHEP |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 100 mM Tris Glycine (pH 7.0), 0.025% ProClin 300 and 20% Glycerol. |
| 抗菌剂 | 0.025% ProClin 300 |
| 稳定剂 | 20% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P37275 Human Zinc finger E-box-binding homeobox 1 Swiss-port # Q64318 Mouse Zinc finger E-box-binding homeobox 1 |
|---|---|
| 基因名称 | ZEB1 |
| 全名 | zinc finger E-box binding homeobox 1 |
| 背景介绍 | This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] |
| 生物功能 | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 124 kDa |
检测图片 (2)
ARG66993 anti-ZEB1 antibody ICC/IF image
Immunofluorescence:4% paraformaldehyde-fixed MDAMB-231 cells were permeabilized with 0.1% NP-40 for 5-10 minutes and blocked with 5% BSA for 30 minutes at room temperature. Cells were stained with ARG66993 anti-ZEB1 antibody at 1:200 dilution.
ARG66993 anti-ZEB1 antibody WB image
Western blot: Mouse miscle tissue stained with ARG66993 anti-ZEB1 antibody at 1:500 dilution.
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