Human ACPA ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
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- 标准范围:
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Brand:
CAT.NO. : ARG80351
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Product Details
概述
| 产品描述 | ARG80351 Human ACPA ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human ACPA (Anti-citrullinated protein antibodies) in serum and plasma. |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | ACPA |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 1 U/ml |
| 样品类型 | Serum and plasma. |
| 标准范围 | 20 - 1000 U/ml |
| 样本量 | 10 µl |
| 別名 | ACPA; Anti-citrullinated protein antibodies; anti-cyclic citrullinated peptides; cyclic citrullinated peptides antibody; CCP antibody; cyclic citrullinated peptides autoantibody; CCP autoantibody; |
应用说明
| 检测时间 | 30, 15, 15, 5 min (RT) |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 背景介绍 | Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. The main characteristic of RA is joint inflammation that results in joint damage and loss of function. An early diagnosis of RA and an immediate beginning of an appropriate treatment is important to prevent a complete joint damage. RA is diagnosed primarily on clinical manifestations and serological support has, up to now, been mainly restricted to the determination of autoantibodies against rheumatoid factor (RF). RF is a sensitive serological marker for RA with a moderate specificity of about 70%. In several studies, it has been demonstrated that the determination of antibodies against citrullinated arginine residues in filament proteins occurs in RF-negative patients. Citrullination is a peptidyl arginine deiminase (PAD) catalyzed process in which the amino acid arginine (Arg) is modified to citrulline. During this conversion, the positively charged NH2-group is hydrolyzed to an oxygen group. ACPA ELISA shows both a high specificity and a high sensitivity for auto-antibodies against citrullinated vimentin. Vimentin is an omnipresent citrullinated protein which was observed in the rheumatoid synovial tissue of RA patients. There are recent findings of secernation and modification of vimentin by macrophages depending on pro-inflammatory signals. The titer of antibodies against vimentin in RA patients strongly correlates with the disease activity score (DAS). |
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| 产品亮点 | Related products: ACPA ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 研究领域 | Signaling Transduction kit |
检测图片 (1)
ARG80351 Human ACPA ELISA Kit standard curve image
ARG80351 Human ACPA ELISA Kit results of a typical standard run with optical density reading at 450 nm.
参考文献
ITGA2 protein is associated with rheumatoid arthritis in Chinese and affects cellular function of T cells
ELISA / Human / Plasma
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