Human BMP7 recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 生物活性:
- 活性说明:
- 別名:
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Brand:
CAT.NO. : ARG70092
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human BMP7 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | BMP7 |
| 物种 | Human |
| A.A. 序列 | Met315 - His431 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is |
| 別名 | BMP-7; OP-1; Osteogenic protein 1; Eptotermin alfa; Bone morphogenetic protein 7 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | 20 mM sodium citrate and 0.2 M NaCl (pH 3.5) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | BMP7 |
|---|---|
| 全名 | bone morphogenetic protein 7 |
| 背景介绍 | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008] |
| 生物功能 | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 翻译后修饰 | Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. [UniProt] |
检测图片 (1)
ARG70092 Human BMP7 recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70092 Human BMP7 recombinant protein (Active) (His-tagged, C-ter).
参考文献
BMP-７によるヒト歯根膜線維芽細胞のセメント芽細胞への分化制御
Functional assay / Human
舌癌におけるコリントランスポーターの局在および増殖細胞との関連
Functional assay / Human
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