Human CD255 / TWEAK recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 生物活性:
- 活性说明:
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Brand:
CAT.NO. : ARG70392
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human CD255 / TWEAK recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD255 / TWEAK |
| 物种 | Human |
| A.A. 序列 | Lys56 - His249 |
| 表达系统 | E. coli |
| Protein Full name | Tumor necrosis factor ligand superfamily member 12 |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce proliferation in HUVEC cells. The ED50 for this effect is |
| 別名 | TNFSF12; TNF Superfamily Member 12; TWEAK; DR3LG; APO3L; Tumor Necrosis Factor (Ligand) Superfamily, Member 12; Tumor Necrosis Factor Ligand Superfamily Member 12; APO3 Ligand; Tumor Necrosis Factor Superfamily Member 12; TNF-Related WEAK Inducer Of Apoptosis; TNF-Related Weak Inducer Of Apoptosis; Tumor Necrosis Factor Ligand 4A; APO3/DR3 Ligand; TNLG4A |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TNFSF12 |
|---|---|
| 全名 | TNF Superfamily Member 12 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |
| 生物功能 | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| 细胞定位 | Cell membrane, Membrane, Secreted |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein |
检测图片 (1)
ARG70392 Human CD255 / TWEAK recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70392 Human CD255 / TWEAK recombinant protein (Active) (His-tagged, C-ter)
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