Human Hemojuvelin ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81905
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG81905-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG81905-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG81905-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG81905-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81905-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81905-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81905-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81905-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG81905-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG81905-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG81905-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG81905 Human Hemojuvelin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Hemojuvelin in serum, plasma (heparin, EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | Hemojuvelin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 78 pg/ml |
| 样品类型 | Serum, plasma (heparin, EDTA) and cell culture supernatants. |
| 标准范围 | 156 - 10000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 6.8%; Inter-Assay CV: 7.5% |
| 別名 | HJV; HFE2A; JH; RGM domain family member C; Hemojuvelin; Hemochromatosis type 2 protein; RGMC |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HFE2 |
| 全名 | hemochromatosis type 2 (juvenile) |
| 背景介绍 | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. [UniProt] |
| 产品亮点 | Related products: Hemojuvelin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HFE2 activity in BMP signaling and thefore iron homeostasis. [UniProt] |
检测图片 (1)
ARG81905 Human Hemojuvelin ELISA Kit standard curve image
ARG81905 Human Hemojuvelin ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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