Human IGFBP2 recombinant protein (His-tagged, C-ter)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 別名:
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Brand:
CAT.NO. : ARG70277
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human IGFBP2 recombinant protein. |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | IGFBP2 |
| 物种 | Human |
| A.A. 序列 | Glu40 - Gln328 of Human IGFBP2 (NP_000588.2) with an initial Met at the N-terminus and 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | IBP-2; IBP2; Insulin-like growth factor-binding protein 2; IGFBP-2; IGF-BP53; IGF-binding protein 2 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IGFBP-2 at 5µg/ml (100 µl/well) can bind Recombinant Human IGF1 with a linear range of 53-212 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 1.0 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P18065 Human Insulin-like growth factor-binding protein 2 |
|---|---|
| 基因名称 | IGFBP2 |
| 全名 | insulin-like growth factor binding protein 2, 36kDa |
| 背景介绍 | The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015] |
| 生物功能 | Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 35 kDa |
| 翻译后修饰 | O-glycosylated. [UniProt] |
检测图片 (1)
ARG70277 Human IGFBP2 recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70277 Human IGFBP2 recombinant protein (His-tagged, C-ter).
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