Human IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter)

Key features and details

  • 产品描述: E. coli expressed, His-tagged (C-ter) Active Human IL17 / IL17A recombinant protein
  • 应用: SDS-PAGE
  • 靶点名称: IL17 / IL17A
  • 物种: Human
  • A.A. 序列: Ile20 - Ala155
  • 表达系统: E. coli
  • 生物活性: Active
  • 活性说明: Determined by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is
  • 別名: IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8
  • Brand:
CAT.NO. : ARG70033
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Product Details
概述
产品描述E. coli expressed, His-tagged (C-ter) Active Human IL17 / IL17A recombinant protein
应用SDS-PAGE
靶点名称IL17 / IL17A
物种Human
A.A. 序列Ile20 - Ala155
表达系统E. coli
生物活性Active
活性说明Determined by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is
別名IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8
属性
形式Powder
纯化说明Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test.
纯度>98% (by SDS-PAGE)
缓冲液PBS (pH 8.0)
复溶It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
存放说明For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
基因名称IL17A
全名interleukin 17A
背景介绍The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
生物功能Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt]
细胞定位Secreted. [UniProt]
产品亮点Related products:
IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins;
Related news:
HMGB1, a biomarker and therapeutic target in COVID-19
翻译后修饰Found both in glycosylated and nonglycosylated forms. [UniProt]
检测图片 (1)
  • ARG70033 Human IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image

    SDS-PAGE analysis of ARG70033 Human IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter).

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