Human IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter)
CAT.NO. : ARG70033
US$ Please choose
US$ Please choose
概述
产品描述 | E. coli expressed, His-tagged (C-ter) Active Human IL17 / IL17A recombinant protein |
---|---|
应用 | SDS-PAGE |
靶点名称 | IL17 / IL17A |
物种 | Human |
A.A. 序列 | Ile20 - Ala155 |
表达系统 | E. coli |
生物活性 | Active |
活性说明 | Determined by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is |
別名 | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
属性
形式 | Powder |
---|---|
纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
纯度 | >98% (by SDS-PAGE) |
缓冲液 | PBS (pH 8.0) |
复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
基因名称 | IL17A |
---|---|
全名 | interleukin 17A |
背景介绍 | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
生物功能 | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
细胞定位 | Secreted. [UniProt] |
产品亮点 | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
翻译后修饰 | Found both in glycosylated and nonglycosylated forms. [UniProt] |
New Products