Human IL36 gamma ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG82785
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Product Details
概述
| 产品描述 | ARG82785 Human IL36 gamma ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human IL36 gamma in serum, plasma (EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | No cross-reactivity with Human IL1 RAcP/Fc Chimera, IL1 Rrp2/Fc Chimera, IL36 alpha (aa. 6-158), IL36 beta (aa. 5-157), IL36RA and Mouse IL36 gamma. |
| 靶点名称 | IL36 gamma |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 18.75 pg/ml |
| 样品类型 | Serum, plasma (EDTA) and cell culture supernatants. |
| 标准范围 | 37.5 - 2400 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | IL-1 epsilon; IL1H1; Interleukin-1 homolog 1; IL-1-related protein 2; Interleukin-36 gamma; IL-1H1; IL-1F9; IL1F9; IL-1RP2; IL1RP2; IL1E; Interleukin-1 family member 9; Interleukin-1 epsilon |
应用说明
| 检测时间 | ~ 3.5 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL36G |
| 全名 | interleukin 36, gamma |
| 背景介绍 | The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019] |
| 生物功能 | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 翻译后修饰 | N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). [UniProt] |
检测图片 (1)
ARG82785 Human IL36 gamma ELISA Kit standard curve image
ARG82785 Human IL36 gamma ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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