Human Lymphotoxin Alpha / TNF beta recombinant protein (Active) (His-tagged, N-ter)

Key features and details

  • 产品描述: E. coli expressed, His-tagged (N-ter) Active Human Lymphotoxin Alpha / TNF beta recombinant protein
  • 应用: SDS-PAGE
  • 靶点名称: Lymphotoxin alpha / TNF beta
  • 物种: Human
  • A.A. 序列: Leu1 - Leu171
  • 表达系统: E. coli
  • Protein Full name: Lymphotoxin-alpha
  • 生物活性: Active
  • 活性说明: Determined by its ability to induce cytotoxicity in L929 cells in the presence of actinomycin D. The ED50 for this effect is3.3x 10^8 IU/mg.
  • Brand:
CAT.NO. : ARG70380
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Product Details
概述
产品描述E. coli expressed, His-tagged (N-ter) Active Human Lymphotoxin Alpha / TNF beta recombinant protein
应用SDS-PAGE
靶点名称Lymphotoxin alpha / TNF beta
物种Human
A.A. 序列Leu1 - Leu171
表达系统E. coli
Protein Full nameLymphotoxin-alpha
生物活性Active
活性说明Determined by its ability to induce cytotoxicity in L929 cells in the presence of actinomycin D. The ED50 for this effect is3.3x 10^8 IU/mg.
別名LTA; Lymphotoxin Alpha; TNFSF1; TNFB; LT; Tumor Necrosis Factor Ligand Superfamily Member 1; Lymphotoxin-Alpha; LT-Alpha; TNF-Beta; Lymphotoxin Alpha (TNF Superfamily, Member 1); Tumor Necrosis Factor Ligand 1E; Tumor Necrosis Factor Beta; TNF Superfamily, Member 1; TNF Superfamily Member 1; TNLG1E
属性
形式Powder
纯化说明Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test.
纯度>98% (by SDS-PAGE)
缓冲液20 mM sodium citrate and 0.2 M NaCl (pH 3.5)
复溶It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
存放说明For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
基因名称LTA
全名Lymphotoxin Alpha
背景介绍The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
生物功能In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
细胞定位Membrane, Secreted
翻译后修饰Glycoprotein
检测图片 (1)
  • ARG70380 Human Lymphotoxin Alpha / TNF beta recombinant protein (Active) (His-tagged, N-ter) SDS-PAGE image

    SDS-PAGE analysis of ARG70380 Human Lymphotoxin Alpha / TNF beta recombinant protein (Active) (His-tagged, N-ter)

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