Human OGG1 recombinant protein (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 別名:
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Brand:
CAT.NO. : ARG70454
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Human OGG1 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | OGG1 |
| 物种 | Human |
| A.A. 序列 | Met1 - Gly345 |
| 表达系统 | E. coli |
| Protein Full name | N-glycosylase/DNA lyase |
| 別名 | OGG1; 8-Oxoguanine DNA Glycosylase; OGH1; MUTM; HOGG1; HMMH; 8-Hydroxyguanine DNA Glycosylase; N-Glycosylase/DNA Lyase; DNA-Apurinic Or Apyrimidinic Site Lyase |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | OGG1 |
|---|---|
| 全名 | 8-Oxoguanine DNA Glycosylase |
| 背景介绍 | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. |
| 生物功能 | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| 细胞定位 | Mitochondrion, Nucleus |
检测图片 (1)
ARG70454 Human OGG1 recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70454 Human OGG1 recombinant protein (His-tagged, C-ter)
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