Human TNFRSF11B / OPG recombinant protein (His-tagged, C-ter)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 別名:
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Brand:
CAT.NO. : ARG70269
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human TNFRSF11B / OPG recombinant protein. |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | TNFRSF11B / OPG |
| 物种 | Human |
| A.A. 序列 | Glu22 - Leu401 of Human TNFRSF11B / OPG (NP_002537.3) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | OCIF; Osteoclastogenesis inhibitory factor; Tumor necrosis factor receptor superfamily member 11B; PDB5; Osteoprotegerin; OPG; TR1 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant human TNFRSF11B at 2 µg/ml (100 µl/well) can bind Recombinant human TNFSF11 with a linear range of 2-8 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O00300 Human Tumor necrosis factor receptor superfamily member 11B |
|---|---|
| 基因名称 | TNFRSF11B |
| 全名 | tumor necrosis factor receptor superfamily, member 11b |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. [UniProt] |
检测图片 (1)
ARG70269 Human TNFRSF11B / OPG recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70269 Human TNFRSF11B / OPG recombinant protein (His-tagged, C-ter).
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