Human TPO / Thyroid Peroxidase autoantibodies ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
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- 标准范围:
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Brand:
CAT.NO. : ARG80892
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Product Details
概述
| 产品描述 | ARG80892 Human TPO / Thyroid Peroxidase autoantibodies ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Thyroid Peroxidase autoantibodies in serum and plasma (EDTA, heparin, citrate) (1:100 diluted). |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | TPO / Thyroid Peroxidase autoantibody |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm |
| 灵敏度 | 5 IU/ml |
| 样品类型 | Serum and plasma (EDTA, heparin, citrate) (1:100 diluted). |
| 标准范围 | 33 - 3,000 IU/ml |
| 样本量 | 10 µl |
应用说明
| 检测时间 | 30, 15, 15, 5 min (RT) |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | Thyreoidal Peroxidase Autoantibodies (TPO-Ab) |
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| 背景介绍 | Thyroid disorders are the most prevalent of all autoimmune diseases. Thyroid autoimmune diseases are associated with the occurrence of differentiated autoantibodies and are thought to be related to a genetical pre-disposition. These autoantibodies are directed against membrane- located and/or extracellular antigens of the thyroid cells: Human Thyroglobulin (hTG), a water soluble glycoprotein with a molecular weight of approx. 660.000 Dalton, is the principal constituent of the thyroidal colloid sharing about 75 % of its mass. Synthesis of the thyroid hormones T3 and T4 is based on the oxidative iodination of tyrosine residues of the thyroglobulin molecule. Within the cell thyroglobulin is transported by the microsomes. Together with the secretion of T3 and T4 also small amounts of hTG are liberated into circulation. The microsomal antigen of the thyroid is an integral membrane protein of the microsomes. It has been characterised as the enzyme Thyroid Peroxidase (TPO) with a molecular weight of nearly 110.000 Dalton. The TSH-Receptor is a regulatory protein embedded into the thyroid cell membrane effecting synthesis and release of the thyroid hormones as well as cellular growth. The so-called Colloid-Antigen 2 CA2. |
| 产品亮点 | Related products: Thyroid Peroxidase antibodies; Thyroid Peroxidase ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 研究领域 | Immune System kit |
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