Mouse Gremlin ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
- 标准范围:
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Brand:
CAT.NO. : ARG82053
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Product Details
概述
| 产品描述 | Mouse Gremlin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse Gremlin in serum, plasma and cell culture supernatants. |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA |
| 靶点名称 | Gremlin |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 46.9 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 93.8 - 6000 pg/ml |
| 样本量 | 100 µl |
| 別名 | GREMLIN; Increased in high glucose protein 2; Gremlin-1; DUP15q; DAND2; CRAC1; MPSH; CKTSF1B1; PIG2; DRM; HMPS1; DAN domain family member 2; IHG-2; HMPS; Cysteine knot superfamily 1, BMP antagonist 1; Cell proliferation-inducing gene 2 protein; C15DUPq; CRCS4; Down-regulated in Mos-transformed cells protein |
应用说明
| 检测时间 | 4.5 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GREM1 |
| 全名 | gremlin 1, DAN family BMP antagonist |
| 背景介绍 | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity). [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 产品亮点 | Related products: Gremlin antibodies; Gremlin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
检测图片 (1)
ARG82053 Mouse Gremlin ELISA Kit standard curve image
ARG82053 Mouse Gremlin ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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