Mouse Neurturin recombinant protein (Active) (His-tagged, N-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 生物活性:
- 活性说明:
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Brand:
CAT.NO. : ARG70459
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (N-ter) Active Mouse NRTN recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | NRTN |
| 物种 | Mouse |
| A.A. 序列 | Cys101 - Val195 |
| 表达系统 | E. coli |
| Protein Full name | Neurturin |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce proliferation in SH-SY5Y cells. The ED50 for this effect is |
| 別名 | NRTN; Neurturin; NTN; Prepro-Neurturin |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | NRTN |
|---|---|
| 全名 | Neurturin |
| 背景介绍 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. |
| 生物功能 | Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Disulfide bond |
检测图片 (1)
ARG70459 Mouse Neurturin recombinant protein (Active) (His-tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70459 Mouse Neurturin recombinant protein (Active) (His-tagged, N-ter)
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