Mouse / Rat DCC ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 检测范围:
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Brand:
CAT.NO. : ARG83268
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Size:
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Product Details
概述
| 产品描述 | ARG83268 Mouse / Rat DCC ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse / Rat DCC in Serum, Plasma and Cell culture supernatants. |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | DCC |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 13 pg/ml |
| 检测范围 | 23.4 pg/ml - 1,500 pg/ml |
| 样品类型 | Serum, Plasma and Cell culture supernatants |
| 精确 | Intra-Assay CV: 6.0% Inter-Assay CV: 5.1% |
| 別名 | Tumor suppressor protein DCC; Immunoglobulin superfamily DCC subclass member 1; CRC18; NTN1R1; MRMV1; Colorectal cancer suppressor; IGDCC1; CRCR1; Netrin receptor DCC |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | DCC |
|---|---|
| 全名 | DCC netrin 1 receptor |
| 背景介绍 | This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] |
| 生物功能 | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 翻译后修饰 | Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. [UniProt] |
检测图片 (1)
ARG83268 Mouse / Rat DCC ELISA Kit standard curve image
ARG83268 Mouse / Rat DCC ELISA Kitresults of a typical standard run with optical density reading at 450 nm.
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